Curtis Joel Ludlow:    Hello everyone, this is Curtis Joel Ludlow with another Boot Camp FX coaching session.

    Today's guest coach is Steve Perrine.
    
    Steve is the author of The New American Diet, Editor of Children's Health Magazine and Editor at large for Men's Health Magazine.

    He says that everything we've been taught weight loss is wrong and in this coaching session. Steve will reveal the revolutionary new plan that will strip away pounds from your belly, change the way you look, feel and live.



    Steve, thank you for taking the time to chat with us.

Stephen Perrine:    Curtis, thank you very much for having me here.

Curtis:    You're welcome. Now, I know your time is limited so let's just get right into it.


     Your new book is The New American Diet: How secret "obesogens" are making us fat and the new superfoods that will flatten your belly for good. Tell me, what is The New American Diet?

Stephen:    Well, a lot of the information that we think of as is, kind of, standard dietary information. It's based on science that was done 40-50 years ago. Science has said things like salmon was a very healthy option cause it was loaded with Omega-3, and steak was a bad option for you. But the reality is that, the food that we ate has changed dramatically since all the traditional food research was done.

    So, The New American Diet looks at food as it is today and talks a lot about why certain foods that we assume are good for us are not necessarily good for us. In certain food that has been "demonized" may actually be healthier choices in some instance.

    And we're talking about, not just meats, we're talking about produce and we reveal, sort of, the information about why these foods are different than the foods that scientists studied and based their assumptions from.

Curtis:    Okay. Now you say there are "obesogens"? What are the obesogens?

Stephen:    Obesogen. The word "obesogen" was a recently coined term by researchers studying something called Endocrine Disrupting Chemicals. You probably heard a lot over the past several months over the chemicals BPA, which is the chemical found in plastic that leach into food. About 93%of American's have FBPA, detectable levels of FBPA in their bodies right now. That means, probably, you and I Curtis.

    And BPA is an estrogenic, it mimics estrogen, it blocks the action of testosterone. And you could, if you know anything about the actions of hormones, you can, kind of, see what that would mean.

    It's as though, each person is getting little, tiny doses of female hormones that undermines muscle growth and increases our body's willingness to store fat.

    So BPA and other chemicals that leach our plastic are "obesogens", they're Endocrine Disrupting Chemicals.

    Pesticides are also endocrine disruptors and the 13 most commonly used pesticides are links to Endocrine Disrupting Action. They have been classified as "obesogens". They are found on our produce, they're found in our drinking water.

    One of the things we talk about in depth is why certain foods, particularly apples, pears, peaches, strawberries, lettuce, they may be very, very healthy for you. Then Franklin said it's "an apple a day, keeps the doctor away". But then Franklin didn't have to worry about what was being sprayed on those apples.

    So when we eat a healthy food but one that may carry 13 different chemicals that cause weight gain. We have to rethink that food. So pesticides are obesogens.

    Hormones, given to these, are obesogens. The average industrially farmed cow has had 6 different hormones, 3 of them natural: testosterone, estrogen and progesterone. And 3 of them are artificial including PBA which is one of the, well actually, is the most powerful steroids used by body builders.

Curtis:    Really.

Stephen:    And we know what a large of dose of PBA does to the human body over a short period of time. No study has ever been done to say what a small dose of PBA administered to the human body over and over and over and over again, does.

    But we do know that PBA, among these other hormones, interfere with the hormonal system. They inspire weight gain, they are obesogens.

    Soy contains two naturally occurring chemicals: genistein and daidzein. These two chemicals are estrogenic and they have the same effect on our bodies as taking estrogen supplements would. Now, in its natural raw form having some edamami or some tofu that's fine but soy is now in all sorts of foods: bread, cereal, cookies.

   We're eating an enormous amount of soy all the time in the chicken that we eat, and the beef that we eat and the pork that we eat, and the fish, that is farmed, that we eat are also eating soy.

    And so because you are what you eat and you are what you eat - eats. We're not only getting soy in our diet but we're getting these chemicals through the animals that we eat which are being fed soy. None of these animals evolved to eat soy. So the soy chemicals in those animals, we're now getting when we eat them. Soy, in these refined forms, is an obesogen.

    And then also we talk about sugars, added sugars, in particular fructose which can interfere with the body's ability to process Leptin.

   Leptin is the hormone that tells you when you are full.

   So if someone who's in what we call the Hypocaloric State, meaning there are no regular basis taking in more calories than you burn. Fructose can quash Leptin response and therefore you always think you are hungry even when you are full. That inspires weight gain; fructose and other sugars are obesogens.

    So the book looks at these various ways that our foods have changed. Atlantic salmon, for example, is a great food to look at. There's no such thing as a wild Atlantic salmon, they're extinct.

Curtis:    Really.

Stephen:    The only Atlantic salmon available today is farmed Atlantic salmon, those fish are fed soy. They are lower in Omega-3 fatty acids, higher in Omega-6 fatty acids. And so the really healthy Omega-3 blast you think you're getting. You're not getting quite as much as you think you are. That healthy pink color that you see on Atlantic salmon fillet, it's not natural. Famed Atlantic salmon are white. When farmers give their salmon these soy pellets, they get to choose from a variety of colors of die that they want in those pellets, to die the salmon's flesh. So that pink flesh you're eating is actually dyed white flesh.

Curtis:    Wow! That is really gross.

Stephen:    It is really gross. 90% of the shrimp that we eat today are farmed shrimp. Farmed shrimps are grown in pits that are essentially like backyard swimming pool, they are loaded with chlorine, pesticides and other chemicals that has been linked to obesity. They are also usually treated with a chemical that prevent them from discoloring during shipment. That chemical is also an obesogen.

So there are all these chemicals being added into our food, so we wanted to see, is there any way of eating that would avoid all these chemicals. And we realized that, you know, you could still eat steaks, pork chops, ice cream, fish, pasta, really anything you crave. As long as you made sure that you've understood the sources and know how to eat them.

And so in the instance of... and I've adapted a lot of these to make grass-fed beasts. And which is very easy to find at places like All Foods or at Joes. I've even found it from time to time at Cosco. And it's also very easy to order over the internet.

Curtis:    Okay.

Stephen:    As you get together and buy a cow every six months. [] have it split up. That's really inexpensive that you can also order it over the internet from a variety of meal or whatever.

Curtis:    Okay.

Stephen:    In eating grass-fed beef, you're not only avoiding the soy, you're also avoiding the hormones and antibiotic which these animals need in order to stay alive and they're being fed a diet of corn and soy. You're getting all of the healthy Omega-3 fatty acids, CLA and the other nutrients that the animals get from... that have been going to your body.

    So you have to think of yourself as, you have to think of your food chain as not being just you and what you eat. But rather it's you and what you eat and what you ate ate and what that ate and all the things that have passed along that food chain. We kind of look at everything in that manner.

Curtis:    Interesting. This is all really fascinating. Now, one of the things that you mentioned was pasta. I found it really interesting, you mentioned that there are antioxidants in pasta.

[Simultaneously talking]

Stephen:    Yeah, you know, even your standard sandwich and Melina pasta does contain some whole grains and its much better to you than white bread and those whole grains do contain antioxidants that are an important and healthy part of eating. So you are getting a dose of whole grain even when you're eating bigger portions of pasta. One of the issues, of course, is that we don't really think about what a portion of pasta should be. It should be about the size of a softball.

Curtis:    Okay.

Stephen:    What about with Alfredo Sausage you get at food chain restaurant.

Curtis:    Sorry my connection cut out there. Now you mentioned ice cream and chocolate. Now, these are superfoods?

Stephen:    Yeah.

Curtis:    Is that correct? How are ice cream and chocolate superfoods?

Stephen:    Well...

Curtis:    The New American Diet superfoods.

Stephen:    Let's be specific, when we talk of ice cream, we're not talking about Chubby Hubby or anything that's named after a comedy central talk show host or something that...

    I want you to really focus on single word ice cream: Vanilla...

Curtis:    Okay.

Stephen:    ...chocolate, coffee, think for the better. I want you to focus, sort of, on the sugar content. When you start adding M&M's and marshmallows and all those other junk into ice cream, that's when it becomes really high in sugar and bad for you.

    But there are a lot of brands out there: 2 of them are Edy's and Breyer's that make excellent choices. And what we'll do is we'll take ice cream and then maybe we'll take some dark chocolate, some nuts, some fruit and throw it on top and mix it in and now you have a really, really healthy dessert that is high in calcium, high in Omega-3, maybe I'll throw some Flax seed on it. And, you know, peanut butter, natural peanut butter, not the stuff with the added sugars.

    And then, you know, as far as chocolate goes, dark chocolate, in particular, is a superfood.

Curtis:    Okay.

Stephen:    ...more than 70% cocoa content. It's high in fiber, very high in antioxidants and it also has the ability to satisfy craving quickly and efficiently. It's very hard to eat dark chocolate because it is so high in fiber, it's so high in nutrients. When we get hungry, we get hungry because our body needs nutrition. And in, you know, out there today in the market place, you could eat all of the calories you want, you'll not get very much nutrition. And so, it's no wonder that we're so hungry all the time.

    If you just focus on filling your meals with nutrients against food, you don't really have to worry that much about calories. Cause it's hard to over eat when you're focusing on nutrition.

Curtis:    Yeah. I'm also looking at [] recommending that people eat boneless, skinless chicken breasts for a long, long time and you mentioned that they contain a lot more fat than they did 30 years ago. Can you...

Stephen:    Sure, this is a great example of how we still go along with plants that is wildly outdated. So yes, 50 years ago, boneless, skinless chicken breasts was a very, very healthy option.

    Today, chicken breasts contains 223% more fats than the boneless, skinless chicken breasts that your grandfather ate. And it contains 63% less protein than the boneless, skinless chicken breast your grandfather ate. It's the same animal but it is a wildly different food. And the reason to that is the animal that your grandfather ate lived out on the backyard, poked around for grubs, ate leaves, ate grasses.

And the animal that we eat today that is commercially farmed is fed soy and corn, things that it has not evolve to eat and should the animal become sick, they're given antibiotic in order to keep them healthy, to keep them alive. And feel like the average farm with chicken is like a little feather covered Keith Richards, ingesting all this stuff, they need constant medical attention to keep them alive. So when you feed an animal junk, the animal gets fat. And when you don't let the animal around to get some exercise, the animal loses his muscle tone. And when you eat the animal, you're eating food that has more fat and less protein.

Curtis:    Well, that makes complete sense and I don't think I'm gonna be able to get that visual of Keith Richards as a chicken out of my head.

Stephen:    But again, there's no reason, why not eat a much, much healthier chicken? And you can find pasture-raised chicken which is also going to be high with omega-3 eggs. You find these in the grocery store all the time. Not because they injected the eggs with omega3. its because they fed the chicken like the chicken was meant to eat.

Curtis:    Okay.

Stephen:    So the chicken-manufactured eggs that are higher in omega3, higher in nutrients that our bodies want, just as organic milk is much higher in nutrients than regular milk. So there are all of these different reasons why eating more traditionally- raised meaning pasture- raised breast fed animals are much, much healthier for us. From getting more nutrition, getting higher levels of protein, exposure to hormones [] on our exposure to antibiotics. All of these things add up.

    And again, what's happening is that eating hamburger a day is bad, there's a little tiny [] and it goes over and over and over again. And right now, there is this, there are more than 1,000 studies being funded with the National Institute of Health looking at the health effects of these chemicals right now.

    That's how worried researchers are about this emerging field. And the Endocrine Society, which is the largest organization of endocrinologists with doctors who study hormones came out with a statement earlier this year linking the increase in these chemicals.
    
    Two days ago, the American Medical Association came out endorsing the Endocrine Society view point and urging more study in this field. So this year alone has become an enormous topic and researchers are very, very concerned. In a year, in a world where one in three children born in the last decade will be diagnosed with diabetes.

Curtis:    Wow.

Stephen:    And adults obesity is a major problem and when people say to me, alright sure, but we eat more than we used to. We watch more TV. We don't exercise. Isn't that the real reason why people are gaining weight. Well look, that plays a role absolutely, calorie gaining, calorie's out plays a role.

    But there's one sector of our population that has seen obesity rate increase 73% in the last 3 decades.

   Infants.

Curtis:    Infants?

Stephen:    So either a 4-month old today are not exercising, as much as the 4-month old that are... previous generations. Or they're climbing out of their cribs and they're hitch hiking to McDonald's or there's something else going on here.

    And that's our point, there is something else going on here. And it's endocrine disruptors. It's obesogens. We need to take it very, very seriously and start protecting ourselves and our families from them.

Curtis:    One more point that I wanted to get to before we end the interview here that's folate, you mentioned folate in the book a little bit and the importance of folate for weight loss and other things particularly for babies. Could you explain that a little bit?

Stephen:    Well, it's fascinating folate in your diet maybe the best individual measure of how healthy your diet is and Americans have stripped fully out of their diet. We've evolved from a society that, number one, ate a lot of leafy greens and number two, ate animals that ate a lot of leafy greens.

    To a society that... [pause] and this animals that subsists mostly on grain. Michael Pollan has made this point in his book but he didn't really drill down to the issue of folate.

   Studies show that people who are dieting with the highest levels of folate will lose eight and a half of times to much weight as dieters who have the lowest levels of folate. Folate is links to, not only, protecting you from depression but solely, actually increases the effectiveness of anti-depression therapies whether it's Serotonin, you know, SSRI's. Like Prozac or whether it's just plain talk therapy.

    And, you know, the most likely explanation for why folate is so powerful as a weight loss tool may have to do with this effect on the brain, it's a mood booster. It also, folate is also carried in foods that are high in fiber so the top sources romaine lettuce, arugula, swiss chard, collard greens. So when you eat more leafy greens of spinach, you're getting the weight loss benefits and you get the mood boosting benefit.

Curtis:    Wow. So you recommend the supplementation with folate or would it be better to take it out from your diet.

Stephen:    Well we always believe it's better to get it from your diet because it's one thing to isolate out folate and, you know, give it as a supplement but the fact is that we know the foods that come rich in folate also come rich in others.

Curtis:    Okay.

Stephen:    With the most important, that are really critical  for weight loss. So we know folate rich creams work. We don't if folate supplements work. So let's go with what we know and let's go what we know will help out in those link. So our recommendation is to try to eat a folate-rich plant at lunch time and at dinner time and to eat it first.

Curtis:    Okay.

Stephen:    So a small salad, a small salad or romaine lettuce. If you order pizza, order the spinach pizza or throw some spinach, order a Cesar salad or throw some spinach into your tomato sauce. I make [] and I'll fry up some [] or some swiss chard, [] put it into the sauce. Those simple things, eat a lot, just a little bit of those green, leafy vegetables.

    Try to make them organic when you can. It's usually very easy to find, organic, romaine and spinach.

    In the book we talk about the dirty dozen, which are the twelve most emphasized, twelve most pesticide-laden pieces of produce. And we'll talk about the clean fifteen which are fifteen pineapples and papayas and avocados.

    Don't spend your money on buying those organic because there's not enough pesticide residue to worry about.

Curtis:    Okay. Well this is all very interesting, where do we get the book The New American Diet?

Stephen:    The book hits bookstores in December 22 but you can get it off of Amazon right now. []


Curtis:    Well, ladies and gentlemen rush out and get a copy of Steve's new book: The New American Diet. It has some really great things in there for you and Steve, thank you so much for being here. I really appreciate it.

Stephen:    Curtis, I really appreciate the opportunity.

Curtis:    Well, that's it for tonight and thanks again.

Shocking FREE Report Reveals Why "Dieting" And Calorie Restriction Do NOT Work, And Shows You Exactly How You Can Use Your Favorite Foods To Easily LOSE (Instead of Gain) 10-15 Pounds This Holiday Season!
Are you interested in using your FAVORITE foods to LOSE fat over the holidays this year?

Then you need to make sure to download Joel Marion's FREE Holiday Fat Loss Black Book report before the page gets pulled tonight at midnight.

Only a few short hours remain to get your hands on 17 different, easy-to-implement holiday weight loss strategies - all 100% FREE.

Strategies #1, 2 and 8 are how I stay fit and lean all year long.

Pick up Joel's report, here:

==> http://CheatYourWaySlim.com

I hope you enjoy this report as much as I did.

Get it here:

==> http://CheatYourWaySlim.com

Have a GREAT FULL DAY and a grateful day!

Curtis Joel Ludlow

You may remember that a few months ago I flew out to Connecticut to help out my buddy Ryan Lee with a seminar he put on.



7 years ago Ryan was a high school gym teacher in the toughest part of the Bronx - working hard for his money.

Well, he learned how to turn his love of fitness into a multi-million dollar online business and now he focuses entirely on teaching other passionate people how to build their businesses.

Anyway, this was his first big live event and he had some really big name speakers there.

One of the most interesting and dynamic speakers was a guy named Jerry Clark.

Jerry found a way to make money that enabled him to RETIRE at the tender age of 23.

Well, Ryan pulled Jerry up on stage and asked him to talk for a minute about the components of success.

His talk was so good, I wanted YOU to hear it too :) so I asked Jerry to condense his talk on the 3 primary components of success.

THE VIDEO ON THIS PAGE IS THAT TALK.

Anyway, when Jerry gave the talk ON STAGE he also showed everyone how they can make $2,000 in 2 minutes.

You can watch THAT video HERE==> http://ContinuitySummit.Net
 

Just as I was, You too will be blown away by Jerry's presentation.

You've gotta see this for yourself right now http://ContinuitySummit.Net

Curtis Joel Ludlow
(714) 414-9942

P.S. Ryan told me he's taking down the videos soon, so get over there right now:

 http://ContinuitySummit.Net

In this video Istvan Javorek demonstrates the Jack Knife exercise. He is 67 years of age.

Watch him pull off 23 in 20 seconds and 35 in in 32 seconds!

 

CSPI Urges Senate to Pass Food Safety Modernization Act

Leafy greens, eggs, and tuna are on the top of a list of the 10 riskiest foods regulated by the Food and Drug Administration. Those and seven other foods account for nearly 40 percent of all foodborne outbreaks linked to FDA-regulated food.

That's no reason to forgo the occasional salad Niçoise, says the Center for Science in the Public Interest, which authored the report, nor need one pass up tomatoes, sprouts, and berries, even though those foods are also on the list.

But the nonprofit watchdog group says the presence of so many healthy foods on such a list is exactly why the United States Senate should follow the House and pass legislation that reforms our fossilized food safety laws.

The FDA is responsible for regulating produce, seafood, egg and dairy products, as well as typical packaged foods such as cookie dough and peanut butter--nearly 80 percent of the food supply. More than 1,500 separate, definable outbreaks were associated with the top 10 riskiest FDA-regulated foods, causing nearly 50,000 reported illnesses.

Since most foodborne illnesses are never reported, these outbreaks are only the tip of a large, hulking iceberg.

"Outbreaks give the best evidence of where and when the food safety system is failing to protect the public," said CSPI staff attorney Sarah Klein, the lead author of the report. "It is clearly time for FDA's reliance on industry self-regulation to come to an end. The absence of safety plans or frequent inspections unfortunately means that some of our favorite and most healthful foods also top the list of the most risky."

CSPI identified 363 outbreaks linked to iceberg lettuce, romaine, spinach, and other leafy greens, variously contaminated with E. coli, Norovirus, or Salmonella, and causing 13,568 cases of illness. Manure, contaminated irrigation water, or poor handling practices are all possible culprits in those outbreaks. The FDA does not currently require farms and processors to have written food safety plans, nor does it provide specific safety standards for even the largest growers to meet.

Eggs were linked 352 outbreaks and 11,163 illnesses; tuna to 268 outbreaks and 2,341 cases of illness, and oysters--despite their limited consumption--to 132 outbreaks causing 3,409 illnesses. Outbreaks involving potatoes don't seem to make headlines, but nevertheless they are linked to 108 outbreaks and 3,659 cases of illness. Cheese, ice cream, tomatoes, sprouts, and berries round out the top 10 list. The data come from CSPI's Outbreak Alert! Database, which includes outbreaks from 1990 to 2006, using data collected from the Centers for Disease Control and Prevention and other sources
.
In July, the House of Representatives passed the Food Safety Enhancement Act with broad, bipartisan support. That measure would give FDA authority to require food processors to design and implement food safety plans, provide specific safety standards that growers would have to meet, and require FDA to visit high-risk facilities every 12 months or less, and most other facilities every 3-4 years. In the Senate, similar legislation, sponsored by Sen. Richard Durbin (D-IL), is pending.

"As consumers, we don't have the power to check on these products," said Kathleen Chrismer, whose 9-year-old daughter Rylee Gustafson was hospitalized for a month after becoming seriously ill from eating spinach salad contaminated with E. coli O157:H7. "Without a better system to protect us, we are totally at the mercy of the next outbreak."

Injecting a therapeutic molecule into muscle appears to jump-start the production of a crucial protein that's missing in patients with Duchenne muscular dystrophy, British researchers report.

The treatment so far is only applicable to about 13 percent of people with the debilitating and ultimately fatal disease, but scientists are hopeful that similar molecules might expand the treatment to a wider range of patients.

Duchenne muscular dystrophy affects about one in 3,500 males, and involves a progressive wasting of muscle due to a genetic inability to produce the protein dystrophin, a key component of muscle structure.

Recently, molecules called antisense oligonucleotides have shown some promise. These molecules work by "skipping over" portions of the defective gene that would otherwise block dystrophin production.

In their study, published online Aug. 25 in The Lancet Neurology, researchers at the University College London Institute of Child Health selected seven patients for whom a particular oligonucleotide molecule, called AVI-4658, appeared suitable. In these patients, the molecule "skipped" exon 51 -- the portion of the dystrophin-blocking gene that appeared to get in the way of effective dystrophin production.

Injecting the molecule into the muscles of these seven patients resulted in increased dystrophin production in all treated muscles, according to a journal news release.

"Intramuscular AVI-4658 was safe and induced the expression of dystrophin locally within treated muscles," the team wrote. "On the basis of these observations, we have initiated a dose-ranging study to assess the safety and efficacy of repeated doses of systemic intravenous AVI-4658."

In a commentary, Annemieke Aartsma-Rus and Gert-Jan van Ommen, from Leiden, the Netherlands, noted that while only about 13 percent of Duchenne muscular dystrophy patients can be expected to be helped by AVI-4658, molecules that skip other exons on the gene could be used, potentially spreading the benefit to more than 70 percent of patients.

What is Muscular Dystrophy?

The muscular dystrophies (MD) are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement. Some forms of MD are seen in infancy or childhood, while others may not appear until middle age or later. The disorders differ in terms of the distribution and extent of muscle weakness (some forms of MD also affect cardiac muscle), age of onset, rate of progression, and pattern of inheritance.

Duchenne MD is the most common form of MD and primarily affects boys. It is caused by the absence of dystrophin, a protein involved in maintaining the integrity of muscle. Onset is between 3 and 5 years and the disorder progresses rapidly. Most boys are unable to walk by age 12, and later need a respirator to breathe. Girls in these families have a 50 percent chance of inheriting and passing the defective gene to their children. Boys with Becker MD (very similar to but less severe than Duchenne MD) have faulty or not enough dystrophin.

Facioscapulohumeral MD usually begins in the teenage years. It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest. It progresses slowly and can vary in symptoms from mild to disabling.

Myotonic MD is the disorder's most common adult form and is typified by prolonged muscle spasms, cataracts, cardiac abnormalities, and endocrine disturbances. Individuals with myotonic MD have long, thin faces, drooping eyelids, and a swan-like neck.
Is there any treatment?

There is no specific treatment to stop or reverse any form of MD. Treatment may include physical therapy, respiratory therapy, speech therapy, orthopedic appliances used for support, and corrective orthopedic surgery.

Drug therapy includes corticosteroids to slow muscle degeneration, anticonvulsants to control seizures and some muscle activity, immunosuppressants to delay some damage to dying muscle cells, and antibiotics to fight respiratory infections. Some individuals may benefit from occupational therapy and assistive technology. Some patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities.

What is the prognosis?

The prognosis for people with MD varies according to the type and progression of the disorder. Some cases may be mild and progress very slowly over a normal lifespan, while others produce severe muscle weakness, functional disability, and loss of the ability to walk.

Duchenne muscular dystrophy is a progressive muscle degenerative disease caused by dystrophin mutations.

There are two emerging therapies designed to repair the primary genetic defect, called 'exon skipping' and 'nonsense codon suppression'.

RECENT FINDINGS: A drug, PTC124, was identified that suppresses nonsense codon translation termination. PTC124 can lead to restoration of some dystrophin expression in human Duchenne muscular dystrophy muscles with mutations resulting in premature stops.

Two drugs developed for exon skipping, PRO051 and AVI-4658, result in the exclusion of exon 51 from mature mRNA. They can restore the translational reading frame to dystrophin transcripts from patients with a particular subset of dystrophin gene deletions and lead to some restoration of dystrophin expression in affected boys' muscle in vivo.

Both approaches have concluded phase I trials with no serious adverse events.

SUMMARY: These therapies act to correct the primary genetic defect of dystrophin deficiency are among the first generation of therapies tailored to correct specific mutations in humans.

Thus, they represent paradigm forming approaches to personalized medicine with the potential to lead to life changing treatment for those affected by Duchenne muscular dystrophy.

People want to get in shape fast.

There are no shortcuts to fitness, but high intensity fitness programs will give your body a rapid transformation. That's where boot camp fitness comes in.

Have you watched "The Biggest Loser" before? The trainers are merciless to the participants in an effort to turn their bodies into fat burning machines. Some people actually like that.

Boot camp fitness is a popular way to exercise. The coach won't yell at you unless you've paid for that type of class. In a gyms, health clubs and other types of programs, many people are turning to more aggressive measures looking for better and speedy fitness results.

Your body can handle a lot. The larger muscle groups of the legs, back, and abs will be challenged through a variety of exercises with and without weights. That is exactly what boot campers thrive on.

Basically the class combines some military PT training with squats, lunges, pushups, crunches, and cardio intervals. You could be running in place or jogging a half mile one minute and doing weight work the next. Those who are looking for a higher intensity workout thrive in  such classes.

Who is a good candidate for boot camp training? All fitness levels can participate, but check with your doctor first. On "The Biggest Loser" the contestants are constantly supervised by a physician. Before beginning any exercise program, especially one as intense as boot camp, it is a good idea to get a clean bill of health.

A good boot camp program will teach something about supportive nutrition so that all of the work done in camp is not in vain. Eating nutritionally supportive meals goes hand in hand with burning fat and reshaping your body.

We've seen the results on shows like "The Biggest Loser." Participants who were hundreds of pounds overweight have lost that weight with kick butt trainers. What about the rest of us? Does boot camp fitness really work?

Burning fat requires commitment, consistency and a burning desire to reshape the body. Boot camp programs deliver quick results, high intensity and a fast total body transformation.

Bootcamp can work for you, too!